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Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)
(Respiratory Physiology & Neurobiology, 2013-01-22)
Abstract.
Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high
altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control
study explores ...
Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction
(Am J Physiol Heart Circ Physiol, 2015-04-27)
Perinatal hypoxia increases susceptibility to high-altitude polycythemia and
attendant pulmonary vascular dysfunction. Am J Physiol Heart Circ
Physiol 309: H565–H573, 2015. First published June 19, 2015;
doi:10.1152/a ...
Unique DNA methylation patterns in offspring of hypertensive pregnancy
(Clin Transl Sci., 2015)
Abstract.
Epigenomic processes are believed to play a pivotal role for the effect of environmental exposures in early life to modify disease risk throughout the lifespan. Offspring of women with hypertensive complications ...
Life-long consequences of postnatal normoxia exposure in rats raised at high altitude
(J Appl Physiol., 2012)
Abstract.
We tested the hypothesis that exposure of high-altitude (HA) rats to a period of postnatal normoxia has long-term consequences on the ventilatory and hematological acclimatization in adults. Male and female HA ...
The relationship between perinatl hypoxia and sleep-disordered breathing in preclinical chronic mountain sickness
(High Altitude Medicine & Biology, 2010-08-08)
Introduction: Chronic intermittent hypoxia due to sleepdisordered breathing is implicated as a potential etiological
factor for chronic mountain sickness (CMS). Whether sleepdisordered breathing precedes or results from ...
Enhanced erythropoietin expression in the brainstem of newborn rats at high altitude
(Neuroscience Letters, 2011)
Abstract.
In addition to its role in elevating red blood cell number, erythropoietin (Epo) exerts protective functions
against acute and delayed degenerative diseases of the brain. Moreover, we have recently demonstrated
that ...
Programmation prénatale de l'acclimatation hématologique et respiratoire chez des rats de haute altitude
(Actas Club Recherché Clinique de Quebec, 2011)
Nous avons testé l’hypothèse selon laquelle l’hypoxie prénatale chez le rat aurait des
conséquences à long terme sur l’acclimatation physiologique à la haute altitude. Des rats
vivant en haute altitude (3600m, La Paz, ...
Effects of prenatal hypoxia on hematological and respiratory acclimatization to high altitude in rats
(Actas Club Recherché Clinique de Quebec, 2011)
We tested the hypothesis that prenatal hypoxia have long-term consequences on
physiological acclimatization to high altitude in rats. Male and female high-altitude rats
(3600m, La Paz, Bolivia) were exposed to normal ...
Hematocrit and hemoglobin levels at adulthood are determined by neonatal hypoxic exposure in rats living at high altitude
(High Altitude Medicine & Biology, 2010-08-08)
Introduction: In previous work performed at sea level we
reported that exposure to neonatal hypoxia impairs ventilatory and hematological responses to chronic hypoxia later in
life. These findings supported the hypothesis ...
Erythropoietin (EPO) in human milk : potential enteral factor in high altitude hypoxia
(High Altitude Medicine & Biology, 2010-08-08)
Introduction: Erythropoietin (Epo) is a normal constituent of
human milk. At sea level, it was found that mean milk-borne
Epo concentrations are within the normal range for plasma
Epo concentrations and rise with ...