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Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA
(The Journal of Maternal-Fetal and Neonatal Medicine, 2012)
Oxidative stress has been implicated in the uteroplacental
ischemia characteristic of preeclampsia and small-for-gestational-age (SGA) birth, both of which are more common at high
(>2500 m) vs low altitude. Since Andeans ...
Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by andean ancestry?
(Reprod Sci., 2010-09)
Abstract.
Objective: This prospective study was designed to determine whether variation in angiogenic
(placental growth factor [PlGF]) and/or anti-angiogenic (soluble fms-like tyrosine kinase [sFlt-1])
factors contribute ...
Andean and Tibetan patterns of adaptation to high altitude
(American Journal of Human Biology, 2013-01-24)
Objectives: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the
ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean ...
High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude
(Am J Physiol Regul Integr Comp Physiol, 2011)
The reduction in
infant birth weight and increased frequency of preeclampsia (PE) in
high-altitude residents have been attributed to greater placental hypoxia, smaller uterine artery (UA) diameter, and lower UA blood ...
Do cytokines contribute to the andean-associated protection from reduced fetal growth at high altitude?
(Reproductive Sciences, 2011)
Abstract.
Pro- versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean ...
Augmented uterine artery blood flow and oxygen delivery protect andeans from altitude-associated reductions in fetal growth
(Am J Physiol Regul Integr Comp Physiol, 2009-02-20)
Abstract.
The effect of high altitude on reducing birth weight is markedly less in
populations of high- (e.g., Andeans) relative to low-altitude origin
(e.g., Europeans). Uterine artery (UA) blood flow is greater ...
Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude
(Physiol Genomics, 2014-07-14)
Low birth weight and intrauterine growth restriction (IUGR) increase the risk of mortality and
morbidity during the perinatal period as well as in adulthood. Environmental and genetic factors contribute to IUGR, but the ...