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Unique DNA methylation patterns in offspring of hypertensive pregnancy
(Clin Transl Sci., 2015)
Abstract.
Epigenomic processes are believed to play a pivotal role for the effect of environmental exposures in early life to modify disease risk throughout the lifespan. Offspring of women with hypertensive complications ...
Comparative responses of arterial oxygen saturation and heart rate durign postnatal development in rats living at high and low altitude
(Actas Club Recherché Clinique de Quebec, 2011)
We used pulse oximetry to measure arterial oxygen saturation (SpO2) and heart rate (HR)
in 4 and 14 day-old rats raised at HA (La Paz, Bolivia, 3,600 m / 12,000ft) or at sea level
(SL, Québec, Canada). SpO2 and HR were ...
Enhanced erythropoietin expression in the brainstem of newborn rats at high altitude
(Neuroscience Letters, 2011)
Abstract.
In addition to its role in elevating red blood cell number, erythropoietin (Epo) exerts protective functions
against acute and delayed degenerative diseases of the brain. Moreover, we have recently demonstrated
that ...
Effects of prenatal hypoxia on hematological and respiratory acclimatization to high altitude in rats
(Actas Club Recherché Clinique de Quebec, 2011)
We tested the hypothesis that prenatal hypoxia have long-term consequences on
physiological acclimatization to high altitude in rats. Male and female high-altitude rats
(3600m, La Paz, Bolivia) were exposed to normal ...