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Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas
(PLOS Genetics, 2012-03-08)
Abstract.
Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors.
Complex historical factors have resulted in varying proportions of ancestral contributions ...
Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)
(Respiratory Physiology & Neurobiology, 2013-01-22)
Abstract.
Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high
altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control
study explores ...
Inhibition of peroxisome proliferator-activated receptor ɣ : a potential link between chronic maternal hypoxia and impaired fetal growth
(FASEB Journal, 2014)
Abstract.
Chronic exposure to hypoxia raises the
risk of pregnancy disorders characterized by maternal
vascular dysfunction and diminished fetal growth. In an
effort to identify novel pathways for these hypoxiarelated ...
Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity
(J Clin Endocrinol Metab, 2014-08)
Context: Uteroplacental hypoxia has been reported to lower estrogen levels in preeclampsia as the
result of reduced aromatase activity.
Objective: We asked whether the chronic hypoxia of residence at high altitude in the ...
Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction
(Am J Physiol Heart Circ Physiol, 2015-04-27)
Perinatal hypoxia increases susceptibility to high-altitude polycythemia and
attendant pulmonary vascular dysfunction. Am J Physiol Heart Circ
Physiol 309: H565–H573, 2015. First published June 19, 2015;
doi:10.1152/a ...
Unique DNA methylation patterns in offspring of hypertensive pregnancy
(Clin Transl Sci., 2015)
Abstract.
Epigenomic processes are believed to play a pivotal role for the effect of environmental exposures in early life to modify disease risk throughout the lifespan. Offspring of women with hypertensive complications ...
Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara
(American Journal of Physical Anthropology, 1998)
Abstract.
Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing ...
Graduated effects of high-altitude hypoxia and highland ancestry on birth size
(Pediatric Research, 2013-10-02)
Background: We present a cohort of ca. 25,000 birth
records from Bolivia of men and women who are currently
adults. We used this cohort to test the hypothesis that high
altitude reduces birth weight and that highland ...
Comparative aspects of high-altitude adaptation in human populations
(Adv. Exp. Med. Biol., 2000)
Abstract.
The conditions and duration of high-altitude residence differ among high-altitude populations. The Tibetan Plateau is larger, more geographically remote, and appears to have been occupied for a longer period of ...
Excessive polycythemia occurs in young high-altitude (3600 m) residents in the absence o lung disease
(Health & height proceeding, 2002)
Summary.
Chronic mountain sickness is present in about 8% of the male population of La Paz. Our question was whether its principal diagnostic sign, excessive polycythemia (EP) without lung disease could be found already ...