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High correlation between Chagas' disease serology and PCR-based detection of Trypanosoma cruzi kinetoplast DNA in Bolivian children living in an endemic area
dc.contributor.author | Wincker, Patrick | |
dc.contributor.author | Bosseno, Marie-France | |
dc.contributor.author | Britto, Constança | |
dc.contributor.author | Yaksic, Nina | |
dc.contributor.author | Cardoso, María Angélica | |
dc.contributor.author | Médicis Morel, Carlos | |
dc.contributor.author | Brenière, Simone Frédérique | |
dc.date.accessioned | 2017-12-18T15:35:28Z | |
dc.date.available | 2017-12-18T15:35:28Z | |
dc.date.issued | 1994 | |
dc.identifier.uri | http://repositorio.umsa.bo/xmlui/handle/123456789/14274 | |
dc.description.abstract | Abstract. The detection of Trypanosoma cruzi kinetoplast DNA by polymerase chain reaction (PCR) amplification is a potentially powerful tool for the parasitological diagnosis of Chagas’ disease. We have applied this technique in a field situation in Bolivia, where 45 children from a primary school were subjected to serological testing, buffy coat analysis and PCR diagnosis. 26 of the 28 serology-positive individuals were also positive by PCR. In addition, two serology-negative children gave a positive result by PCR, including one who was positive in the buffy coat test. These results suggest that PCR detection of T. cruzi DNA in blood can be a very useful complement to serology in Chagas’ disease diagnosis in Bolivia. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | FEMS Microbiology Letters | es_ES |
dc.subject | TRYPANOSOMA CRUZI | es_ES |
dc.subject | ENFERMEDAD DE CHAGAS | es_ES |
dc.subject | ADN DE KINETOPLAST | es_ES |
dc.subject | DIAGNÓSTICO POR PCR | es_ES |
dc.title | High correlation between Chagas' disease serology and PCR-based detection of Trypanosoma cruzi kinetoplast DNA in Bolivian children living in an endemic area | es_ES |
dc.type | Article | es_ES |